Premium
THE EFFECT OF RENAL DENERVATION ON ACTH‐INDUCED HYPERTENSION IN SHEEP
Author(s) -
Whitworth Judith A.,
Denton D. A.,
Graham W. F.,
Humphery T. J.,
Scoggins B. A.,
Coghlan J. P.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00152.x
Subject(s) - denervation , natriuresis , endocrinology , medicine , blood pressure , sodium , kidney , chemistry , organic chemistry
SUMMARY 1. The effect of renal denervation on ACTH‐induced hypertension in sheep has been examined. 2. Both intact and renally denervated sheep showed similar rises in blood pressure following ACTH treatment. 3. Following renal denervation, the initial urinary sodium retention and ACTH‐withdrawal natriuresis typical of ACTH administration in intact sheep were absent, and the fall in blood pressure was delayed.