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CIRCULATING HYPOTENSIVE FACTOR IN PREGNANT SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Kubota T.,
Yamada T.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00143.x
Subject(s) - blood pressure , endocrinology , medicine , pregnancy , prolactin , prostaglandin , estrone , hormone , alpha (finance) , biology , surgery , construct validity , genetics , patient satisfaction
SUMMARY 1. Blood pressure decreased significantly at a late stage of pregnancy in spontaneously hypertensive rats (SHRs) but this reduction tended to disappear shortly after delivery. Since acute and chronic administration of progesterone, prolactin and estrone failed to reduce blood pressure, these hormones were not responsible for a fall of blood pressure at a late stage of pregnancy in SHRs. Exogenous administration of prostaglandin E 2 (PGE 2 ) significantly reduced blood pressure, but endogenous prostaglandin E 1 (PGE 1 ), PGE 2 and prostaglandin F 2α (PGF 2α ) in plasma did not increase at a late stage of pregnancy. 2. Plasma from pregnant SHRs produced a significant reduction of blood pressure in male and female SHRs, but the plasma from male and non‐pregnant female SHRs failed to reduce blood pressure. Plasmas from pregnant SHRs were less effective in reducing blood pressure when tested in Wistar Kyoto rats (WKYs). 3. It is concluded that a hypotensive factor is circulating at a late stage of pregnancy in SHRs.