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ALTERED CARDIAC NORADRENALINE STORES IN DOCA‐SALT HYPERTENSIVE RATS
Author(s) -
Howe P. R. C.,
West M. J.,
Chalmers J. P.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00137.x
Subject(s) - medicine , endocrinology , in vivo , norepinephrine , sympathetic activity , chemistry , heart rate , blood pressure , biology , dopamine , microbiology and biotechnology
SUMMARY 1. The storage of noradrenaline (NA) in hearts of DOCA‐salt hypertensive rats was examined after in vivo administration of labelled NA. 2. The cardiac N A concentration and the neuronal NA storage capacity were reduced in these rats compared with normotensive controls. The extent of reduction was dependent on the duration of hypertension. 3. These findings are similar to observations on spontaneously hypertensive rats and support the hypothesis that storage of the cardiac sympathetic transmitter is impaired in DOCA‐salt hypertension.