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BARORECEPTOR REFLEX IN THE RAT AFTER CONVERTING ENZYME INHIBITION OR ANGIOTENSIN RECEPTOR BLOCKADE
Author(s) -
Coleman Thomas G.,
Salgado Maria Cristina O.,
Bengis Roy G.,
Davis Milton H.,
Dent Ann C.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00136.x
Subject(s) - baroreflex , baroreceptor , phenylephrine , endogeny , medicine , reflex bradycardia , reflex , renin–angiotensin system , angiotensin ii , blood pressure , heart rate , endocrinology , angiotensin converting enzyme
SUMMARY 1. One component of baroreflex responsiveness was quantitated in conscious rats using the heart rate response to a pressor injection of phenylephrine. 2. Endogenous angiotensin and its effectiveness were manipulated by sodium deprivation, converting enzyme inhibition and infusion of an angiotensin analogue. None of these manoeuvres changed the observed reflex responsiveness. 3. We conclude that endogenous angiotensin has no influence on the component of baroreceptor function that is described by the slope of the arterial pressure‐heart rate relationship.