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IN‐VIVO MODIFICATION OF ANGIOTENSIN 11 PRESSOR RESPONSIVENESS IN SHEEP BY INDOMETHACIN
Author(s) -
Beilby David S.,
Coghlan John P.,
Denton Derek A.,
Graham William F.,
Humphery Timothy J.,
Scoggins Bruce A.,
Whit worth Judith A.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00131.x
Subject(s) - angiotensin ii , endocrinology , medicine , in vivo , renin–angiotensin system , pressor response , chemistry , prostaglandin , sodium , blood pressure , biology , heart rate , microbiology and biotechnology , organic chemistry
SUMMARY 1. Sodium (Na) depletion, due to uncompensated loss of parotid saliva, reduces the pressor responsiveness to angiotensin II (AII) in intact conscious sheep. 2. Inhibition of prostaglandin synthesis by indomethacin restored All pressor responsiveness in Na‐deplete sheep. 3. Indomethacin infusion also increased the pressor responsiveness to AII in the Na‐replete sheep. 4. These findings suggest that in vivo prostaglandins may play a role in modulating the pressor responsiveness to angiotensin II in sheep.