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THE HYPOTENSIVE RESPONSE TO COMPOUND 48/80 IN NORMOTENSIVE AND HYPERTENSIVE RATS
Author(s) -
Kirkendol Paul L.,
Cauvin Cynthia A.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00122.x
Subject(s) - histamine , blood pressure , endocrinology , medicine , pressor response , spontaneously hypertensive rat , chemistry , heart rate
SUMMARY 1. The administration of an initial dose of 50 μg/kg of 48/80 produced a sharp fall in the blood pressure of normotensive rats but produced little change in blood pressure in spontaneously hypertensive rats. 2. The administration of an additional 50 μg/kg and 100 μg/kg of 48/80 in normotensive and spontaneously hypertensive rats resulted in equivalent decreases in pressure in both groups. 3. Both groups had equivalent decreases in blood pressure in response to methylhistamine. 4. Spontaneously hypertensive rats appear to have a reduced ability to release histamine in response to 48/80 due to either an increased threshold for 48/80 or a diminished histamine storage pool.