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TESTOSTERONE‐ANTIBIOTIC EFFECTIVENESS ON STAPHYLOCOCCUS AUREUS INFECTED RATS
Author(s) -
Atef M.,
Sokkar S. M.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00118.x
Subject(s) - oxytetracycline , penicillin , testosterone propionate , antibiotics , chloramphenicol , staphylococcus aureus , testosterone (patch) , pharmacology , microbiology and biotechnology , endocrinology , medicine , chemistry , biology , androgen , bacteria , hormone , genetics
SUMMARY (1) Male castrated rats (testosterone‐free) inoculated intraperitoneally with Staph, aureus showed severe damage in their internal organs as determined by pathological examination of the killed animals. (2) Penicillin‐G, oxytetracycline and chloramphenicol treatment 24 h after injection markedly decreased the extent of damage. (3) Pretreatment of castrated rats with testosterone propionate for 3 successive days before infection had a protective influence on the internal organs. (4) Testosterone‐injected rats when treated with different antibiotics, showed a clear synergistic action with penicillin‐G and oxytetracycline but not chloramphenicol.