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THE INFLUENCE OF DIETHYL MALEATE ON THE BILIARY EXCRETION OF INFUSED SULPHOBROMOPHTHALEIN SODIUM AND ITS GLUTATHIONE CONJUGATE IN GUINEA‐PIGS
Author(s) -
Whelan Gregory
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00117.x
Subject(s) - glutathione , chemistry , medicine , conjugate , endocrinology , excretion , sodium , guinea pig , conjugated system , biochemistry , mathematical analysis , mathematics , organic chemistry , enzyme , polymer
SUMMARY 1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea‐pigs pretreated intraperitoneally with 0 7 ml of diethyl maleate to depress hepatic glutathione levels. 2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake. 3. Unconjugated BSP transport was also depressed markedly as a result of (a) a reduction in the intrahepatic conjugation of BSP with glutathione and (b) suppression of conjugated BSP excretion.