Premium
EFFECT OF β‐ADRENORECEPTOR BLOCKADE ON THE RENIN RESPONSE TO ACUTE NATRIURESIS
Author(s) -
Vandongen Robert,
Barden Anne,
Tunney Anne
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00115.x
Subject(s) - propranolol , plasma renin activity , natriuresis , blockade , diuretic , discontinuation , medicine , endocrinology , renin–angiotensin system , furosemide , diuresis , pharmacology , kidney , blood pressure , receptor
SUMMARY 1. The response of plasma renin activity to frusemide 40 mg given intravenously, was examined before and after oral propranolol 160 mg daily for 7 days in normal and hypertensive subjects. 2. Although basal renin levels were often reduced, the increase following frusemide was essentially unaltered by propranolol therapy. 3. These findings indicate that enhanced renin activity associated with diuretic use may not be prevented by concurrent propranolol administration. Limitation of the hypotensive action of combined β‐blocker diuretic therapy can therefore be anticipated. 4. Preservation of the renin stimulatory effect of frusemide during beta blockade confirms the value of this procedure in the investigation of mineralo‐corticoid and renovascular hypertension where discontinuation of treatment may be undesirable.