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EFFECT OF ACTH ADMINISTRATION ON THE HAEMODYNAMIC RESPONSE TO ARGININE‐VASOPRESSIN IN SHEEP
Author(s) -
Coghlan John P.,
Denton Derek A.,
Graham William F.,
Humphrey Timothy J.,
Mason Rex T.,
Schnieder Edward G.,
Scoggins Bruce A.,
Whitworth Judith A.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00111.x
Subject(s) - vasopressin , medicine , bradycardia , endocrinology , heart rate , blood pressure , cardiac output , hemodynamics , reflex bradycardia , arginine , reflex , chemistry , biochemistry , amino acid
SUMMARY 1. Blood pressure, heart rate and cardiac output were studied in intact conscious sheep during AVP infusion at 0.1, 0.25, 0.5 and 10 μg/min for 30 minutes to determine whether pressor responsiveness to AVP was altered in ACTH‐induced hypertension. 2. Prior to ACTH treatment, AVP produced rises in blood pressure associated with a fall in heart rate and cardiac output. 3. During ACTH treatment, pressor responsiveness to AVP and decrease in cardiac output were unchanged, but reflex bradycardia was reduced. 4. ACTH‐induced hypertension in sheep is not associated with enhanced pressor responsiveness to AVP.