Premium
ANGIOTENSIN CONVERTING ENZYME IN THE BRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Mendelsohn F. A. O.,
Hutchinson J. S.,
Csicsmann J.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00109.x
Subject(s) - medicine , endocrinology , hypothalamus , striatum , medulla oblongata , hippocampus , cerebral cortex , spontaneously hypertensive rat , central nervous system , cerebellum , angiotensin converting enzyme , angiotensin ii , cortex (anatomy) , enzyme , chemistry , blood pressure , biology , dopamine , biochemistry , neuroscience
SUMMARY 1. Angiotensin converting enzyme (ACE) was measured in homogenates of regions of rat brain using the substrate Hip‐His‐Leu. 2. The enzyme resembled classical ACE in its marked CI” dependence and inhibition by both SQ 20,881 (25 μmol/1) and EDTA (1 mmol/1). 3. Spontaneously hypertensive rats (SHR) and normotensive Wistar‐Kyoto controls (NT‐WK) were killed at 20‐22 weeks of age and their brains dissected into eight regions. 4. There were marked region variations of ACE with highest levels in striatum, hippocampus, cerebellum and pituitary and lower levels in hypothalamus and cerebral cortex. 5. In three brain regions ACE was significantly lower in SHR compared to NT‐WK: medulla oblongata ( P <0.05), hypothalamus ( P <0‐02) and cerebral cortex ( P < 005). In the other sites the levels were not different. 6. These region‐specific differences of ACE in the SHR could lead to altered production or metabolism of central neuropeptides postulated to be involved in the control of blood pressure.