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THE EFFECTS OF MECLOFENAMATE ON RENAL AND PERIPHERAL VASCULAR BEDS IN CONSCIOUS RABBITS
Author(s) -
Banks R. A.,
Beilin L. H.,
Soltys J. S.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00105.x
Subject(s) - vasodilation , vascular resistance , peripheral resistance , perfusion , peripheral , renal cortex , medicine , cortex (anatomy) , cardiac output , kidney , renovascular hypertension , anesthesia , endocrinology , hemodynamics , biology , neuroscience
SUMMARY 1. Meclofenamate caused a dose‐dependent increase in renovascular resistance in conscious rabbits. 2. This effect was greatest in inner cortical zones at the highest dose (6 mg/kg) but at the lowest dose (0‐75 mg/kg) vascular resistance in the outer cortex was preferentially increased. 3. In contrast, meclofenamate increased cerebral perfusion and the proportion of cardiac output received by the testis. No effect was demonstrated on other organs studied. 4. The results suggest a local vasodilator influence of renal prostaglandins in normal conscious rabbits.