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INCREASED SODIUM PERMEABILITY OF ERYTHROCYTES IN SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Wiley J. S.,
Hutchinson J. S.,
Mendelsohn F. A. O.,
Doyle A. E.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00104.x
Subject(s) - sodium , permeability (electromagnetism) , chemistry , medicine , biophysics , biology , biochemistry , membrane , organic chemistry
SUMMARY 1. The Na permeability of red cells from spontaneously hypertensive rats (SHR) has been studied. In the Japanese Wistar‐Kyoto strain, a significant increase of 30% in 22 Na influx for male SHR was found compared with normotensive male controls. In contrast the Na influx for genetically hypertensive and normotensive New Zealand rats did not differ. Normotensive Wistar‐Kyoto rats rendered hypertensive by unilateral renal artery clipping, did not show any difference in Na influx from control animals. 2. These results suggest that the Japanese strain of SHR has a genetically determined increase in erythrocyte Na permeability.