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REDUCED RESPONSES TO NORADRENALINE OF ISOLATED DIGITAL ARTERIES FROM HYPERTENSIVES
Author(s) -
Moulds Robert F. W.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00100.x
Subject(s) - medicine , cardiology , chemistry
SUMMARY 1. Strips of digital arteries obtained post‐mortem from thirteen hypertensives have been compared with those from thirteen normotensives. 2. The strips from hypertensives and from males had a significantly greater response to 80 mmol/1 KCl, but this was due to the increased cross‐sectional areas of the strips from hypertensives and from males. 3. The maximum responses to noradrenaline and serotonin, but not the p ED 50 values, were significantly smaller in the strips from the hypertensives than in those from the normotensives, but there were no differences between the strips from hypertensives and normotensives in either the maximum response or pED 50 values to angiotensin or barium chloride. 4. It is concluded that these results suggest a decreased number of α‐receptors are present in human hypertensive vascular smooth muscle and this is a sequel either of the increased pressure itself, or of increased exposure in vivo of the blood vessels from hypertensives to noradrenaline.