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ACTH HYPERTENSION MODIFIES THE HAEMODYNAMIC EFFECTS OF PROSTACYCLIN INFUSIONS IN SHEEP
Author(s) -
Mason R. T.,
Allen K. J. F.,
Coghlan J. P.,
Denton D. A.,
Fei D. T.,
Graham W. F.,
Scoggins B. A.,
Stewart K. W.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00093.x
Subject(s) - prostacyclin , cardiac output , hemodynamics , stroke volume , blood pressure , medicine , heart rate , vascular resistance , endocrinology , mean arterial pressure , anesthesia
SUMMARY 1. The haemodynamic effects of short‐term prostacyclin infusions (0.05‐0 50 /μg/kg per min) were investigated in conscious adult sheep. 2. Haemodynamic dose‐response curves to prostacyclin were performed before, during and after production of ACTH‐induced hypertension. 3. Prior to ACTH administration prostacyclin produced dose‐dependent reductions in mean arterial pressure, total peripheral resistance and stroke volume and these were accompanied by increases in heart rate and cardiac output. 4. After 5 days of ACTH‐induced hypertension prostacyclin produced similar effects on mean arterial pressure to those seen prior to ACTH but the effects on heart rate, cardiac output, stroke volume and total peripheral resistance were markedly increased. 5. These studies demonstrate that the responsiveness of the circulation to prostacyclin is altered in ACTH‐induced hypertension.