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RENIN SECRETION AND RENAL VASCULAR RESISTANCE FOLLOWING PROLONGED ADMINISTRATION OF DESOXYCORTICOSTERONE (DOC) IN RATS DRINKING NORMAL SALINE
Author(s) -
Vandongen R.,
Tunney Anne
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00087.x
Subject(s) - saline , medicine , endocrinology , vascular resistance , plasma renin activity , renin–angiotensin system , blood pressure , isoprenaline , kidney , secretion , stimulation
SUMMARY 1. The effect of long‐term administration of desoxycorticosterone (DOC)‐saline on arterial blood pressure, renal vascular resistance and renin secretion rate was studied in the rat. 2. Renin secretion rate and peripheral plasma renin activity was markedly reduced in the DOC‐saline treated rats. Renal vascular resistance was comparable to that found in a corresponding control group. Responsiveness to isoprenaline suggested that the β ‐adrenoceptor mediating renin release was grossly intact. 3. A significant rise in blood pressure occurred in only 50% of the treated animals: However, no differences in weight gain, renal vascular resistance or renin levels were apparent when compared with animals which remained normotensive. 4. These findings indicate that suppression of renin secretion during prolonged DOC‐saline administration cannot be directly attributed to changes in arterial pressure, renal vascular resistance or β ‐adrenoceptor sensitivity.