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THE INFLUENCE OF DIBUTYRYL ADENOSINE CYCLIC MONOPHOSPHATE ON CELL PROLIFERATION IN THE EPITHELIUM OF THE JEJUNAL CRYPTS, THE COLONIC CRYPTS AND IN COLONIC CARCINOMATA OF RAT
Author(s) -
Tutton P. J. M.,
Barkla D. H.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00071.x
Subject(s) - crypt , cell growth , endocrinology , medicine , epithelium , biology , cell , 1,2 dimethylhydrazine , cell division , hormone , chemistry , dimethylhydrazine , biochemistry , colorectal cancer , cancer , genetics
SUMMARY 1. Cell proliferation in the jejunal crypts, the colonic crypts and in dimethyl‐hydrazine (DMH)‐induced adenocarcinomata of rat colon was measured using a stathmokinetic technique. 2. Dibutryl cyclic adenosine monophosphate (dibutyryl cAMP) was found to inhibit cell proliferation in colonic crypts and in colonic adenocarcinomata. 3. Dibutryl cAMP at very high doses was found to inhibit jejunal crypt cell proliferation but at lower doses was found to accelerate jejunal crypt cell proliferation. 4. Neither bilateral adrenalectomy nor chemical sympathectomy was found to abolish the ability of dibutryl cAMP to stimulate jejunal crypt cell proliferation. 5. The present results are difficult to interpret in terms of known hormonal influences on cell proliferation in the tissues examined and of established actions, of these hormones on cyclic nucleotide metabolism in other tissues.