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HAEMODYNAMIC INTERACTIONS BETWEEN α‐ AND β‐ADRENO‐CEPTOR ANTAGONISTS IN CONSCIOUS OR ANAESTHETIZED RATS
Author(s) -
Oates Helen F.,
Stoker Lynette M.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00067.x
Subject(s) - phentolamine , propranolol , antagonist , bradycardia , hemodynamics , medicine , adrenergic antagonist , stimulation , anesthesia , heart rate , endocrinology , blood pressure , receptor
SUMMARY 1. The α‐adrenoceptor antagonist, phentolamine, was administered intravenously, to conscious or anaesthetized rats, before or after the β‐adrenoceptor antagonist, propranolol. 2. The bradycardia which followed the combined administration of propranolol and phentolamine exceeded that induced by propranolol alone, yet the hypotensive effect of phentolamine was attenuated by propranolol. 3. The results are compatible with the concept that a significant part of the hypotensive effect of phentolamine is mediated by stimulation of vascular β‐adrenoceptors.