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STUDIES ON INTERACTION OF TIMOLOL, HYDROCHLOROTHIAZIDE AND AMILORIDE IN THE RAT
Author(s) -
Scriabine A.,
Watson L. S.,
Ludden C. T.,
Russo H. F.,
Bohidar N. R.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00063.x
Subject(s) - amiloride , hydrochlorothiazide , timolol , pharmacology , medicine , chemistry , endocrinology , sodium , blood pressure , ophthalmology , intraocular pressure , organic chemistry
SUMMARY 1. The acute effects of hydrochlorothiazide, amiloride, timolol and their combinations on diuresis and arterial pressure were studied in rats. 2. Timolol did not modify the diuretic and saluretic effects of hydrochlorothiazide and/or amiloride and had no diuretic or antidiuretic effects alone. 3. At a single dose of 1 25 mg/kg, p.o., timolol alone had no antihypertensive effect in spontaneously hypertensive rats. 4. The antihypertensive effect of hydrochlorothiazide + amiloride+timolol was significantly greater than with any of the drugs alone.