Premium
DIFFERENTIAL CHRONOTROPIC AND INOTROPIC EFFECTS OF 2‐NICOTINAMIDOETHYL NITRATE (SG‐75) IN THE DOG ISOLATED ATRIUM
Author(s) -
Chiba S.,
Furukawa Y.,
Kobayashi M.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00062.x
Subject(s) - chronotropic , verapamil , inotrope , atrium (architecture) , medicine , contractility , cardiology , chemistry , anesthesia , heart rate , blood pressure , calcium , atrial fibrillation
SUMMARY 1. The chronotropic and inotropic effects of the anti‐anginal agent SG‐75 (2‐nicotinamidoethyl nitrate) and 1 ‐verapamil were investigated in isolated blood‐perfused canine atrial preparations. The compounds were administered via the cannulated sinus node artery. 2. SG‐75 induced a selective negative inotropic as opposed to a chronotropic effect. Verapamil showed no selective negative chronotropic or inotropic activity. 3. Effects of SG‐75 and 1 ‐verapamil on the frequency‐force relationship were studied. SG‐75 produced a uniform depression of the developed tension at all frequencies tested which the depression with 1 ‐verapamil was greater at higher than at lower frequencies.