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COMPARISON OF THE VASCULAR EFFECTS OF ADENOSINE, AMP, ADP AND ATP ON ISOLATED BLOOD‐PERFUSED INTERNAL AND EXTERNAL CAROTID ARTERIES OF DOGS
Author(s) -
Chiba S.,
Ohhashi T.,
Azuma T.
Publication year - 1980
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1980.tb00060.x
Subject(s) - vasodilation , adenosine , vasoconstriction , adenine nucleotide , carotid arteries , adenosine diphosphate , medicine , artery , chemistry , anesthesia , cardiology , endocrinology , nucleotide , biochemistry , platelet , platelet aggregation , gene
SUMMARY 1. The effects of adenosine and adenine nucleotides were studied on arterial vasculature in blood‐perfused arterial preparations of dogs which were isolated from the internal and external carotid arteries. Each compound was administered directly into the cannulated artery over a period of 4 s. 2. In both arterial preparations, adenosine produced a dose‐related vasodilatation and was more potent than AMP. On the other hand, ATP produced a dose‐related vasoconstriction and was more potent than ADP.