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EFFECT OF VERATRUM ALKALOIDS ON RIGHT AND LEFT ATRIAL RECEPTORS IN THE CAT
Author(s) -
Fahim M.
Publication year - 1979
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1979.tb01251.x
Subject(s) - veratridine , receptor , medicine , pco2 , cats , cardiology , endocrinology , anesthesia , chemistry , sodium , sodium channel , organic chemistry
Summary 1. The effects of veriloid and veratridine on right and left atrial receptors have been studied in cats. 2. Threshold doses of these drugs for right atrial receptors were found to be almost twice those for left atrial receptors. Beyond threshold doses, however, the dose‐response curves were similar. 3. The sensitivity of left atrial receptors to veratridine was not altered by an increase in P CO2 and/or decrease in P O2 of left atrial blood. Therefore, the difference in the behaviour of left and right atrial receptors to these drugs is not due to the differences in P O2 and P CO2 of blood in the two atria. They are more likely to be a feature of the regenerative regions of the receptors.