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Comparison of the bronchodilator and vasodilator activity of sodium azide and sodium nitroprusside in the guinea‐pig
Author(s) -
Jamieson Dana D.,
Taylor K. M.
Publication year - 1979
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1979.tb00034.x
Subject(s) - sodium nitroprusside , sodium azide , chemistry , pharmacology , bronchodilatation , vasodilation , guinea pig , in vivo , inhalation , sodium , bronchodilator , anesthesia , medicine , nitric oxide , biochemistry , biology , organic chemistry , asthma , microbiology and biotechnology
Summary 1. Sodium azide and sodium nitroprusside are potent dilators of the intact guinea‐pig tracheal preparation in vitro. 2. Both substances are bronchodilators in the anaesthetized guinea‐pig in vivo when administered intravenously or by aerosol inhalation. 3. Sodium azide and sodium nitroprusside are also potent vasodilators in the guinea‐pig. 4. At all doses and by any route of administration, including aerosol inhalation, the hypotensive effect predominates over bronchodilatation.