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The Influence of Intraperitoneally Injected 6‐Hydroxydopamine on Electroshock Seizure in Chicks and Rats
Author(s) -
Osuide G.,
Wambebe C.
Publication year - 1979
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1979.tb00023.x
Subject(s) - hydroxydopamine , endocrinology , seizure threshold , medicine , tonic (physiology) , epilepsy , anticonvulsant , dopamine , dopaminergic , psychiatry
Summary 1. 6‐Hydroxydopamine, injected intraperitoneally in rats and chicks, did not induce spontaneous seizures but produced significant alterations in the threshold to electroshock seizure in chicks; the particular effects were dose‐dependent and time‐dependent. 2. Administration of 6‐hydroxydopamine to 3 day old chicks and rats in the first and third days after birth resulted in an increase in the proportion exhibiting tonic seizure with electroshock when tested after 10–12 weeks. 3. When 6‐hydroxydopamine was injected intraperitoneally into adult rats and cocks, there was no significant alteration in seizure threshold. 4. The results suggest that 6‐hydroxydopamine penetrates the central nervous system of young chicks and rats and that adrenergic mechanisms are probably involved in modulating seizure mechanisms in both the chick and rat.