Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists

11th Annual Meeting, 23‐25 November 1977, Sydney1. The effect of medroxyprogesterone pretreatment on barbiturate‐induced sleep in mice . M. Willow, L. B. Cobbin and R. Malor 2. The effect of ethinyloestradiol pretreatment on barbiturate‐induced sleep in mice. M. Willow, R. Malor and L. B. Cobbin 3. Impairment of hepatic drug metabolism in alcoholics. A. W. Harman, C. B. J. Alexander, D. B. Frewin and B. G. Priestly 4. Toxicity of bromobenzene in isolated rat hepatocytes. N. H. Stacey and B. G. Priestly5. Contribution of increased metabolic inactivation to the development of tolerance to ethanol in the rat . Jeanette M. Wood and R. Laverty 6. The inhibition of aryl hydrocarbon hydroxylase activity in rat liver microsomes by a 2‐n‐alkylbenzimidazole homologous series . A. J. Ryan and P. J. Little 7. Enflurane toxicity in the presence of renal impairement. M. J. Cousins, A. Fulton, B. D. G. Haynes and R. Whitehead 8. Identification by GC/MS of some quinine metabolites in urine . C. Liddle, S. Bhuwapa‐thanapun, R. K. Christopher, G. G. Graham and A. M. Duffield 9 Patterns of drug metabolism in man . D. J. Birkett and A. Conney 10. Effects of foetal and neonatal exposure to dicophana (DDT) in the rat . M. E. Dean, T. C. Smeaton and B. H. Stock. 11. Species variation in sensitivity of liver glutathione levels to paracetamol in vitro J. C. Y. Tsui and N. P. Madsen (introduced by C. Raper) 12. Hepatic glutathione depletion associated with rifampicin and isoniazid administration. K. Ng, J. Stone, M. Rose, A. Ryan and J. Ham 13. Development of the cytochrome P450 system in a marsupial, the quokka (Setonix brachyurus). M. E. McManus, K. F. Dett and J. K. McGeachie 14. The effects of cadmium on rat liver microsomal haemoproteins . P. G. Peters and B. G. Priestly 15. Dose‐, route‐ and sex‐related differences in the effects of cadmium on hepatic cytochrome P450‐dependent metabolism in the rat . D. Hawke, P. G. Peters and B. G. Priestly 16. Absorption and metabolism of [ 14 C]carprofen in man . J. E. Ray, D. N. Wade and G. G. Graham 17. Interaction of levamisole and aspirin in man . P. M. Brooks, M. S. Roberts, R. Rumble and N. Johnson 18. Slow‐release emulsions of narcotic antagonists, physical dependence and brain amines . M. R. Fennessy and F. J. Laska 19. Increased antagonist potency of naloxone caused by morphine pre treatment in mice .C. L. Wong and G. A. Bentley 20. Comparison of the self‐injection rate of nicotine, methadone and saline in rats in the presence of a distractor bar . D. Jefferys, G. Singer and T. P. Oei 21. Self‐administration of nicotine by rats . W. J. Lang, A. Latiff, A. McQueen and G. Singer 22. Analeptic activity in the mouse of methylcamphors . E. Solomon and J. S. Robertson 23. Physical dependence in the rat after chronic Δ 9 ‐tetrahydrocannabinol . M. R. Fennessy and D. A. Taylor 24. Clomipramine antagonism of Δ 9 ‐tetrahydrocannabinol effects in the rat . D. A. Taylor and M. R. Fennessy 25. Structure‐activity relationship of enkephalin analogues. M. J. Quinn, F. J. Laska and M.R Fennessy 26. Behavioural and reflex changes after intracisternal injection of 6‐hydroxydopamine . P. I. Korner, J. R. Oliver, J. A. Reynoldson, G. A. Head and V. Carson 27. The quasi‐morphine withdrawal syndrome: its attenuation by Δ 9 ‐tetrahydrocannabinol and other non‐narcotic drugs . S. G. Zaluzny, G. B. Chester, D. M. Jackson and R. Malor 28. The influence of cannabinoid pretreatment on the duration of anaesthesia induced by various agents in the mouse . J. Frizza, G. B. Chesher, D. M. Jackson, R. Malor and G. A. Starmer 29. The effect of intracerebral applied dopamine on conditioned avoidance responding in rats . P. Braes and D. M. Jackson 30. Evidence for the role of octopamine as a neurotransmitter in the clam. D. F. H. Dougan and D. N. Wade 31. The effect of antipsychotic drugs on apomorphine‐induced rearing in rats . Y. Iskander, D. Dougan and D. N. Wade 32. The effect of dopamine, noradrenaline and various antagonists on phospholipid turnover in striatal synaptosomes . H. M. Allars and D. N. Wide 33. Central dopamine and noradrenaline receptor sensitivity after an acute dose of pimozide . Robin Dunstan, D. M. Jackson and N.‐E. Andén 34. Dexamphetamine‐ and apomorphine‐induced supersensitive dopamine receptors in the mouse . R. Bailey and D. M. Jackson 35. Mechanism of the potentiating action of 4‐aminopyridine on vasoconstrictor responses of the rabbit ear artery. W. E. Glover 36. Studies on the adrenergic innervation of cerebral microvasculature . J. Baird‐Lambert and S. Spector (introduced by K. M. Taylor) 37. Effects of methysergide on the constrictor response to 5‐hydroxytryptamine on the rabbit ear artery . P. R. Carroll and P. E. Nasveld 38. Effect of catecholamines on the increased vascular permeability induced by inflammatory agents . Gayle O'Duffy and Loris A. Chahl 39. Central modulation of the depressor response to carotid sinus nerve stimulation during vertebral artery infusion of angiotensin II. G. C. Scroop, J. D. Marker and T. S. Miles 40. Haemodynamic responses to suspension of clonidine or guanfacine treatment in the rat . H. F. Oates, E. P. MacCarthy, L. M. Stoker and G. S. Stokes 41. Cardiac effects of Sydney funnel‐web spider venom (FWSV) . D. Morgans, E. J. Myle‐charane, J. W. Duckworth, P. R. Carroll and W. E. Glover 42. Single dose evaluation of a new sustained release aspirin (S‐RA) . M. S. Roberts, P. Patel and P. M. Brooks 43. Factors controlling the cardioselectivity of β‐adrenoceptor antagonists . A. J. Coleman, D. S. Paterson, A. R. Somerville and J. L. Wale (introduced by M. J. Rand) 44. Further studies with clenbuterol in cat and guinea‐pig preparations . E. Malta, P. E. Kearney and C. Raper 45. Is prazosin a selective postjunctional α‐adrenoceptor antagonist? H. M. Cole and D. F. Story 46. The effect of prazosin on pre‐ and post‐junctional α‐adreonceptors in the pithed rat . A. S. P. Hua and R. F. W. Moulds 47. Differential effects of prazosin on human vascular preparations . R. A. Jauernig, R. F. W. Moulds and J. Shaw 48. Excessive lacrimation on fluorouracil therapy associated with detectable concentrations of 5FU in tears and plasma . N. Christophidis, F. J. E. Vajda, I. Lucas, O. Drummer, W. J. Moon and W. J. Louis 49. The pharmacokinetics of salicyclate in patients with rheumatoid arthritis. G. Graham, G. D. Champion, R. O. Day, T. M. Haavisto and P. D. Paull 50. Anomalous salicyclate transfer in an in vitro rat intestine preparation . P. Paull and D. N. Wade 51. Phenytoin absorption in states of malabsorption . M. Kennedy and D. N. Wade 52. Spectrophotofluorometric evidence for co‐operative binding of warfarin and phenylbutazone to bovine serum albumin. R. W. Hall and B. W. Madsen (introduced by J. W. P&teison) 53. Protein‐binding during haemodialysis . S. P. Myers and D. J. Birkett 54. Plasma protein binding of etidocaine in pregnancy . D. J. Morgan and J. Thomas 55. Serum protein binding of drugs during and after pregnancy–studies in humans . M. F. Dean, B. H. Stock and G. Levy 56. Pharmacokinetics of melphalan following oral or intravenous administration in patients with malignant disease . M. H. N. Tattersall, M. Jarman, E. S. Newlands, L. Holyhead, R. A. V. Milstead and A. Weinberg 57. Use of saliva in the measurement of phenytoin concentrations . S. N. Anavekar, R. H. Saunders, W. M. Wardell, I. Shoulson, F. G. Emmings, A. Gringeri and C. E. Cook 58. Disposition of clonidine in the rat as determined by radioimmunoassay . B. Jarrott and S. Spencer 59. Warfarin levels in anticoagulated patients . P. Duffield, A. Duffield, M. Kennedy, D. J. Birkett and D. N. Wade 60. Enhanced clearance of antipyrine in anaesthetists exposed to volatile anaesthetics . A. W. Harman, W. J. Russell, D. B. Frewin and B. G. Priestly 61. The effects of a‐agonist and antagonist drugs on cardiovascular responses to somatic afferent nerve stimulation . R. M. Brazenor and G. A. Bentley 62. Relative affinities of some imidazoline compounds for a‐receptors in rat vascular smooth muscle . E. R. Hepburn and G. A. Bentley 63. Studies on the mode of action of St91 [2‐(2,6‐diethylphenylamino)‐2‐imidazoline hydrochloride] , an analogue of clonidine. P. L. McLennan and G. A. Bentley 64. Evidence for the existence of multiple subtypes of β‐adrenoceptor in the rat heart . C. Sadavongvivad, V. Prachayasittikul, P. Sanvarinda and S. Saneha (introduced by M. J. Rand) 65. A short‐acting pressor substance isolated from the kidney. E. Burcher and G. Macdonald (introduced by P. Carroll) 66. Comparison of the bronchodilator and vasodilator activity of sodium azide and sodium nitroprusside in the guinea‐pig . D. D. Jamieson and K. M. Taylor 67. Alteration of myocardial oxygen consumption and coronary blood flow by sodium nitroprusside in the dog . M. J. Brown 68. Comparison of the α‐adrenoceptor antagonizing properties of oxprenolol and labetalol in isolated human arteries . R. A. Jauernig, R. F. W. Moulds, J. Hobson, M. Stevens and J. Shaw 69. Comparison of the a‐adrenergic and H 2 ‐histaminergic effects of clonidine [2‐(2,6‐dichlorophenylamino)‐2‐imidazole hydrochloride] and St476 [2‐(2,3‐dichlorophenyI‐amino)‐2‐imidazole hydrochloride) . I. C. Medgett and M. W. McCulloch 70. Effects of withdrawal of clonidine treatment on pre‐junctional α‐adrenoreceptor sensitivity in rat atria. H. Majewski and D. F. Story 71. Dopamine as a false noradrenergic transmitter . W. Hope, H. Majewski, M. McCulloch, M. J. Rand and D. F. Story 72. Activation of the renin‐angiotensin system during hypercapnia in the dog . Janina Staszewska‐Barczak 73. Cardiovascular effects evoked from nociceptive cardiac receptors and by hypothalamic stimulation in the dog . Janina Staszewska‐Barczak, R. Padanyi and W. J. Lang 74. Towards specific methods for hydralazine assay . P. A. Reece and R. Zacest 75. Determination of indomethacin by electron‐capture gas‐liquid chromatography . S. Aldous, P. M. Brooks and T. M. Haley 76. Fluorimetric and spectrometric determination of gallamine triethiodide in plasma and urine. M. I. Ramzan and E. J. Triggs (introduced by J. Thomas) 77. A radioimmunoassay for tricylcic antidepressants . K. P. Maguire, G. D. Burrows, T. R. Norman and B. A. Scoggins 78. The measurement of carbamazepine and its epoxide metabolite by high pressure liquid chromatography in epileptic patients. G. Mihaly, J. Phillips and F. Vajda 79. Isolation of Δ 9 ‐tetrahydrocannabinol from marihuana and its determination in serum. D. G. Ferry, E. G. McQueen, N. K. McCallum and E. R. Cairns 80. Evaluation of a competitive protein binding assay for prednisolone . Julia M. Potter, G. Dean and U. Mueller (introduced by J. W. Paterson) 81. Clinical applications of isotope derivative assays for maprotiline . T. R. Norman, G. D. Burrows, K. P. Maguire and B. A. Scoggins 82. Plasma carbamazepine‐10, 11‐epoxide levels in epileptic patients . L. Mckauge, F. Bochner, M. J. Eadie and J. H. Tyrer 83. Factors influencing plasma ethosuximide levels in epileptic patients . G. A. Smith, J. H. Tyrer and M. J. Eadie 84. Pharmacokinetics of prazepam in man . M. Collins, L. Evans, J. H. Tyrer and M. J. Eadie 85. The relationship between the therapeutic effect and plasma level of haloperidol. L. Evans, J. Cox, R. Van Dijk, M. J. Eadie, J. E. Penny, J. Price, J. Tyrer and M. Weston 86. Plasma haloperidol levels in man during high‐dosage therapy with the drug . J. E. Penny, L. Evans, M. J. Eadie and J. H. Tyrer 87. The effect of food on the disposition of radioactivity in rats after administration of [ 14 C]haloperidol . M. J. Patterson, B. W. Madsen and K. F. Ilett 88. Pharmacokinetics of ticrynafen and its pharmacological effects in normal volunteers . A. J. Wood, P. Bolli, H. J. Waal‐Manning and F. O. Simpson 89. The disposition of dexamethasone in humans . S. E. Tsuei, R. G. Moore, J. J. Ashley and W. G. McBride 90. Pharmacokinetic studies of timolol in man . A. Bobik, G. L. Jennings, P. Ashley and P. I. Korner 91. Histamine levels in brain, spinal cord and heart of genetically hypertensive rats . P. R. C. Howe, J. P. Chalmers, J. Muller, J. C. Provis and M. J. West 92. The effect of histamine on the response of the rabbit ear artery to noradrenaline . R. C. Hall and A. Foldes 93. Actions of some imidazol compounds on histamine H 2 receptors in guinea‐pig ventricular strips . P. E. Kearney, E. Malta and C. Raper 94. Histamine treatment in histaminic cephalalgia‐a study of 123 cases over a period of 3 years . M. Thomas and T. Bhanu (introduced by J. N. Pennefather) 95. How do sulphonylureas work? G. M. Shenfield, A. Logan, D. Shirling, J. Baird (introduced by J. W. Paterson) 96. Combined bronchodilator therapy . G. E. Marlin, N. Berend and A. C. Harrison 97. Drug interactions in isolated cat airways smooth muscle . H. W. Mitchell and M. A. Denborough 98. Effects of compound 48/80 on the cat lung and trachea . K. M. Lulich and J. A. Paterson 99. The effects of some monochlorophenethanolamine derivatives in vivo in cats . L. G. Letts, D. M. Temple and L R. Williams 100. Factors affecting pulmonary inactivation of prostaglandin E 2 (PGE 2 ) in the rat. A. L. A. Boura and R. D. Murphy 101. The effects of monomethylphenethanolamine derivatives on β‐adrenoceptors of guinea‐pigs in vitro. P. A. Easson, D. M. Temple, L. R. Williams and C. H. lim 102. The use of an in vivo guinea‐pig model to study the pharmacological properties of indo‐ramin. C. Hamer and D. Temple 103. Effect of acute and chronic morphine of rat brain histamine levels. S. J. Lewis and M. R. Fennessv 104. Circulatory effects following intradsternal injection of 6‐hydroxydopamine . P. I. Korner, J. R. Oliver, J. A. Reynoldson, G. A. Head, V. Carson and M. Walker 105. Pre‐synaptic inhibition of noradrenaline release in guinea‐pig hypothalamus by cloni‐dine and guanfacine. B. J. Bryant and D. F. Story 106. Cyclic AMP and opiate analgesia . A. W. Duggan and B. T. Griersmith 107. Conditional cardiovascular responses induced by cocaine in guinea‐pigs and dogs . J. W. Ross and W. J. Lang 108. Maintenance of self‐administration of nicotine with body weight changes . G. Singer, W. J. Lang and F. Simpson 109. Further evidence in support of behaviourally conditioned immunosuppression . E. A. Wayner and G. Singer 110. Adrenaline, phenylethanolaminevt‐methyltransferase and α‐methyldopa in rat brain . P. M. Beart, L. Conway, B. Jairott, W. J. Louis and D. Prosser 111. The antimuscarinic action of stercuronium in guinea‐pig atria. C. K. Li and F. Mitchel‐son 112. Altered sensitivity of the muscarinic acetylcholine receptor induced by chronic administration of the anticholinesterase agent di‐isopropyl fluorophosphate (DFP) . G. D. Schiller and D. H. Overstreet 113. Evidence for axonal transport of a stable pool of ATP in cholinergic nerves. L. P. Davies and V. P. Whittaker (introduced by K. M. Taylor) 114. Drug information for doctors. M. E. Murray 115. Cardiological studies with nomifensine, a new antidepressant P. Dumovic, G. D. Burrows, J. Vohra and S. E. Freeman 116. The effects of counselling on patient drug compliance failure . G. S. M. Kellaway 117. Does propranolol have a peripheral vascular effect in man? R. F. W. Moulds, J. D. Hobson, R. A. Jauernig, C. Macklin and J. Shaw 118. The time course of heart rate and blood pressure changes after oral timolol . G. Jennings, A. Bobik, P. Jenkins and P. I. Korner 119. Clinical effects of single dose guanfacine administration in hypertension. E. P. Mac‐Carthy, P. Isaac, G. Frost, A. Freeman and G. Stokes 120. Clinical applications of a semiautomatic, non‐invasive, portable blood pressure recorder (Remler M2000). E. P. MacCarthy, I. R. Thornell and G. S. Stokes 121. Haemodynamic adjustments during antihypertensive pharmacotherapy. R. Zacest, L. L. Wilson, M. A. Robinson, J. R. Graham and C. D. Miller 122. A comparison of the hypotensive and metabolic effects of clopamide and metazolone. J. D. F. England and J. Shaw 123. An open study of zimelidine in endogenous depression. J. Cox, G. Moore and L. Evans 124. Dopamines‐hydroxylase in serum of patients with migraine . M. Anthony, J. W. Earl and H. Hinterberger 125. Use of drugs in a Western Australian rural community . B. W. Madsen, P. Weeks, N. S. Stenhouse, K. Wearne (introduced by J. W. Paterson) 126. Comprehension of medication regimes and instructions by patients who do not speak English as their native tongue . J. Shaw, M. P. Hemming, J. D. Hobson and J. J. Marty 127. A comparison of the efficacy of atenolol with either propranol or prindolol in the management of hypertension . D. B. Frewin, A. W. Harman, R. K. Penhall and B. G. Priestly 128. Contractile responses to α‐adrenoceptor agonists in vasa deferentia from rats treated with testosterone and noregestrel . R. A. Charlwood, J. N. Pennefather and G. M. Handberg 129. Adrenoceptors mediating twitch inhibition in the rat vas deferens . S. D. Shipley, J. N. Pennefather and G. M. Handberg 130. Uterus‐atria selectivity of three sympathomimetic uterine relaxants in guinea‐pig . Stella R. O'Donnell and Janet C. Wanstall 131. Field stimulation‐induced release of noradrenaline from a preparation of guinea‐pig ovary and ovarian ligament . J. A. Farrar, G. M. Handberg and J. N. Pennefather 132. Non‐invasive sampling in studying erythromycin pharmacokinetics? L. E. Mather, K. L. Austin, P. J. McDonald and C. R. Philpot 133. Predicting methotrexate toxicity. J. J. Marty, J. R. Marriage and J. Shaw 134. Interactive simulation in pharmacokinetics . K. L Austin and L. E. Mather