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Comparison of vaccination of mice and rats with Haemophilus influenzae and bordetella pertussis as models of atopy
Author(s) -
Terpstra G. K.,
Raaijmakeis J. A. M.,
Kreukniet J.
Publication year - 1979
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1979.tb00018.x
Subject(s) - vaccination , haemophilus influenzae , bordetella pertussis , medicine , pertussis vaccine , immunology , eosinophilia , atopy , monocytosis , vaccination schedule , allergy , microbiology and biotechnology , immune system , biology , immunization , antibiotics , bone marrow , genetics , bacteria
Summary 1. Rats and mice were vaccinated with Haemophilus influenzae in different vaccination schedules whereafter blood eosinophils were counted. In rats a single vaccination resulted in a dose‐dependent effect on the blood eosinophil count in a pattern comparable with that after BordeteUa pertussis vaccination. In a long‐term vaccination schedule (five times a week for 5 weeks) rats developed a constant eosinophilia. In mice a single vaccination resulted in an eosinopenia of a consistent pattern which differed from the response after BordeteUa pertussis vaccination; in a long‐term vaccination schedule, eosinophilia was evoked for a period of about 13 days: 2. Thirty minutes after an adrenaline injection in vaccinated rats and mice with Haemophilus influenzae , hyperglycaemic and eosinophilic responses were measured. The eosinophilic response after adrenaline was inhibited in both species; the hyperglycaemic response in rats was unaltered, in mice the response was slightly but significantly ( P < 0.05) decreased. 3. The sensitivity to several drugs was tested in mice, 5 days after vaccination with Haemophilus influenzae or BordeteUa pertussis. Haemophilus influenzae vaccination reduced the isoprenaline sensitivity and increased the noradrenaline sensitivity. BordeteUa pertussis vaccination reduced the isoprenaline sensitivity while the sensitivity to histamine and adrenaline was raised. 4. The Haemophilus influenzae vaccinated experimental animal provides a model that is possibly more related to human atopy than the BordeteUa pertussis vaccinated animal.