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Reduced adenosine 3′,5′cyclic monophosphate levels in patients with reversible obstructive airways disease
Author(s) -
Krzanowski J. J.,
Poison J. B.,
Goldman A. L.,
Ebel T. A.,
Szentivanyi A.
Publication year - 1979
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1979.tb00013.x
Subject(s) - adenosine , adenosine monophosphate , medicine , cyclic adenosine monophosphate , pulmonary disease , cardiology , endocrinology , receptor
Summary 1. Patients were grouped into categories of ‘no airways disease’, ‘obstructive airways disease without response to bronchodilator’ and ‘obstructive airways disease with bronchodilator responsiveness’. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of adenosine 3′,5′‐cyclic monophosphate (cyclic AMP) were found in pulmonary tissue obtained from patients with reversible obstructive airways disease, lending support to the β‐adrenergic theory of asthma.