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COMPARISON OF THE ANORECTIC AND MOTOR ACTIVITY EFFECTS OF SOME AMINOINDANES, 2‐AMINOTETRALIN AND AMPHETAMINE IN THE RAT
Author(s) -
Mrongovius R. I.,
Bolt A. G.,
Hellyer R. O.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00719.x
Subject(s) - anorectic , fenfluramine , amphetamine , motor activity , chemistry , pharmacology , endocrinology , food intake , medicine , biochemistry , receptor , serotonin , dopamine
SUMMARY 1. The anorectic and motor activity effects of 1‐aminoindane, 2‐aminoindane, some N‐substituted 2‐aminoindanes,2‐aminotetralin, amphetamine and fenfluramine were determined in rats. 2. The two compounds with structures most like the extended conformation of amphetamine, 2‐aminotetralin and 2‐aminoindane, were potent anorectics. At dosages which halved the intake of food over 1 h, amphetamine increased motor activity, 2‐aminotetralin had no effect, and 2‐aminoindane reduced motor activity.’ 3. Both the anorectic and central stimulant actions of 2‐aminoindane were absent in N‐ethyl‐ and N‐isopropyl‐2‐aminoindane. 4. 1‐Aminoindane, whose structure is like the folded conformation of amphetamine, produced a small anorectic effect and depressed motor activity.