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CARDIAC EFFECTS OF SALBUTAMOL‐INDUCED HYPOKALAEMIA IN THE CONSCIOUS DOG
Author(s) -
Wahlqvist M. L.,
Shanahan E. A.,
Dennis P. M.,
Pullan P. T.,
Wilmshurst E. G.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00717.x
Subject(s) - salbutamol , medicine , hypokalemia , anesthesia , cardiology , pharmacology , asthma
SUMMARY 1. Infusion of salbutamol (3.0 μg/min after a bolus injection of 100 μg) produced hypokalemia in conscious dogs. 2. Measurement of arterial and coronary sinus potassium differences revealed no significant potassium loss from the heart with established hypokalaemia. 3. Shortly after the initial salbutamol bolus and before steady‐state hypokalaemia had been achieved during salbutamol infusion, a prolongation of QT C occurred; this corresponded to a significant myocardial potassium loss of ‐0.12 mmol/1 plasma. 4. Urinary electrolyte excretions indicated that the hypokalaemia was not due to urinary potassium loss. 5. It was deduced that potassium had moved intracellularly. No change in hydrogen ion status occurred to account for this. Pronounced rises in plasma insulin immunoreactivities during salbutamol infusions suggested this as one mechanism for potassium shifts.