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INTRARENAL ACTION OF ANGIOTENSIN II IN RESTORING RENAL ARTERY PRESSURE AFTER ACUTE RENAL ARTERY STENOSIS
Author(s) -
Anderson W. P.,
Korner P. I.,
Johnston C. I.,
Angus J. A.,
Casley D. J.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00706.x
Subject(s) - renal artery stenosis , medicine , renal artery , cardiology , blood pressure , renal artery obstruction , angiotensin ii , action (physics) , kidney , physics , quantum mechanics
SUMMARY 1. The renal artery of conscious dogs was acutely narrowed over 30 s to reduce renal artery pressure distal to the stenosis to 40 mmHg and the stenosis was maintained for 1 h. The distal renal artery pressure was rapidly restored to a plateau slightly below pre‐stenosis values within 10–15 min. Rises in systemic blood pressure and plasma renin activity were small and transient. 2. This restoration was an active process, mediated by the intrarenal effects of angiotensin II (AH), since it was greatly diminished or abolished when the renal artery was narrowed in the presence of angiotensin I‐converting enzyme inhibitor or angiotensin receptor antagonist (l‐Sar‐8‐Ue All). However, it was not diminished by ‘total’ autonomic effector blockade. 3. This angiotensin II‐mediated restoration of renal artery pressure may be of homeostatic significance for the maintenance of glomerular filtration rate.