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EFFECT OF SOME PROSTAGLANDIN SYNTHESIS INHIBITORS ON THE ANTINOCICEPTIVE ACTION OF MORPHINE IN ALBINO RATS
Author(s) -
Srivastava D. N.,
Bhattacharya S. K.,
Sanyal A. K.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00703.x
Subject(s) - morphine , nociception , pharmacology , prostaglandin , chemistry , medicine , receptor , biochemistry
SUMMARY 1. Five prostaglandin synthesis inhibitors, indomethacin, diclofenac, mefenamic acid, ibufen and paracetamol, were found to inhibit the antinociceptive action of morphine without affecting the antinociceptive response of an equi‐analgesic dose of prostaglandin E 1 2. Diclofenac was found to be the most potent and longest acting, whereas paracetamol was the least potent and shortest acting. Indomethacin, mefenamic acid and ibufen occupied an intermediate position, both in potency and duration of action. 3. The results suggest that prostaglandins may be involved in the antinociceptive action of morphine in albino rats.