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EFFECTS OF VARIOUS DRUGS ON THE OSMOTIC LYSIS OF RAT MAST CELLS
Author(s) -
Day R. O.,
Wade D. N.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00700.x
Subject(s) - histamine , flufenamic acid , phenylbutazone , pharmacology , chemistry , mast cell , probenecid , lysis , intracellular , biochemistry , medicine , immunology
SUMMARY 1. Rat mast cells were exposed to low osmotic pressures to produce a ‘nonspecific’ disruption of the mast cell, with release of histamine along with other intracellular contents. 2. The effect of non‐steroidal anti‐inflammatory drugs and various other drugs upon osmotically induced histamine release was examined. 3. Representative non‐steroidal anti‐inflammatory drugs indomethacin, phenylbutazone and flufenamic acid, the acidic compounds ethacrynic acid, iopanoic acid and probenecid, and the local anaesthetic lignocaine, all caused a dose‐dependent facilitation of osmotically induced histamine release compared to controls. All drugs were active at 0.1 mmol/1. 4. The previously observed inhibition of compound 48/80 and the antigen‐induced histamine release from rat mast cells by similar concentrations of the drugs used in the present study are unlikely to be due to mast cell plasma membrane stabilization.