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CONVERSION OF ANGIOTENSIN I TO ANGIOTENSIN II IN SHEEP
Author(s) -
Fernley R. T.,
Coghlan J. P.,
Cran E. J.,
Fei T. W.,
Scoggins B. A.,
McGregor A.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00695.x
Subject(s) - angiotensin ii , renin–angiotensin system , medicine , endocrinology , chemistry , venous blood , sodium , angiotensin iii , angiotensin receptor , blood pressure , organic chemistry
SUMMARY 1. The methodology for measurement of angiotensin I in whole blood is described. 2. Angiotensin I was measured in arterial and venous blood samples from sodium‐loaded, sodium‐replete and sodium‐depleted sheep. Venous blood concentrations were higher than arterial angiotensin I concentrations. Arterial angiotensin I concentrations increased with increasing sodium deficiency. 3. Angiotensin II was infused into six sodium‐replete sheep, the blood concentrations of angiotensin II measured and the metabolic clearance rates calculated. The average value was 121 ± 21 1/h. 4. Angiotensin I was then infused into these sheep and arterial and venous blood concentrations of angiotensins I and II determined. From this data and the metabolic clearance rate of angiotensin II, the degree of conversion of angiotensin I to II was calculated. The values varied in different sheep from 54 ± 2% to 105 ± 6% ( n = 6).