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ALTERATIONS EM LEVELS OF VASCULAR HISTAMINE IN THE DOCA‐HYPERTENSIVE RAT
Author(s) -
Holcslaw T. L.,
Imhoff L.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00691.x
Subject(s) - histamine , medicine , abdominal aorta , endocrinology , vasodilation , mast cell , aorta , femoral artery , immunology
SUMMARY 1. Histamine was detected in the abdominal aorta and the femoral arteries of normotensive and also DOCA‐hypertensive rats. 2. Levels of total histamine (mast cell and non‐mast cell histamine) were significantly reduced in both abdominal aorta and the femoral artery of the DOCA‐hypertensive rats, relative to the normotensive controls. 3. It is suggested that the diminished level of vascular histamine may be related to the development and/or maintenance of the hypertensive state and is also related to the reduced magnitude of active reflex vasodilatation.