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THROMBOXANE B 2 INHIBITS PROSTAGLANDIN E 2 INACTIVATION BY THE RAT ISOLATED PERFUSED LUNG
Author(s) -
Boura A. L. A.,
Murphy R. D.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00688.x
Subject(s) - thromboxane , mepyramine , methysergide , chemistry , prostaglandin e , prostaglandin , endocrinology , medicine , lung , propranolol , contraction (grammar) , prostacyclin , thromboxane b2 , thromboxane a2 , pharmacology , platelet , biochemistry , receptor , antagonist
SUMMARY 1. The effect of thromboxane B 2 (T×B 2 ) on inactivation of prostaglandin E 2 (PGE 2 ) by the rat isolated perfused lung has been studied. 2. TxB 2 when infused in low concentrations (100 ng/ml) into the pulmonary artery reduced PGE 2 inactivation approximately two‐fold. 3. The rat isolated fundus strip was contracted by higher concentrations of TxB 2 (1.0 Mg/ml) in the presence of hyoscine, mepyramine, methysergide, phenoxy‐benzamine and propranolol. The size of contraction was reduced by indomethacin in concentrations known to inhibit prostaglandin synthetase. 4. Thus, in circumstances in which T×B 2 and PGE 2 are released concomitantly by the lung, low concentrations of TxB 2 may augment PGE 2 release by reducing its inactivation.