Premium
THE CONTRACTION INDUCED BY CALCIUM IONS IN ISOLATED GUINEA‐PIG VAS DEFERENS
Author(s) -
Sugjmoto J.,
Furumichi A.,
Murakami M.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00686.x
Subject(s) - vas deferens , contraction (grammar) , isotonic , guinea pig , calcium , sucrose , sodium , chemistry , medicine , endocrinology , biochemistry , organic chemistry
SUMMARY 1. When isolated guinea‐pig vas deferens was pretreated with 0.01% sodium edetate in an isotonic sucrose medium and then transferred to an edetate‐free sucrose medium, the addition of CaCl 2 (1.1 to 35.2 mmol/1) induced a contraction. 2. The contraction was greatest when the CaCl 2 was added soon after pretreat‐ment with edetate, and decreased with increasing time, almost disappearing after 1h. 3. When KC1 (1.4 to 22.4 mmol/1) was added in place of CaCl 2 , the contraction was lowest soon after pretreatment with edetate, and increased with time; after 1 h, the effect was 80.7% of that observed in a preparation that had not been pretreated with edetate.