PROCEEDINGS OF THE AUSTRALASIAN SOCIETY OF CLINICAL AND EXPERIMENTAL PHARMACOLOGISTS

10th Annual Meeting, 25‐26 November 1976, Adelaide1. Histamine metabolism in aortae of two histamine sensitive species. A. Foldes, M. J. Stacey and I. S. de la Lande 2. Localization of histamine in rabbit central ear artery . M. J. Stacey, A. Foldes and I. S. de la Lande 3. Effects of antigen and compound 48/80 on the guinea‐pig lung and trachea . K. M. Lulich and J. W. Paterson 4. The effect of various drugs on compound 48/80 and osmotic shock‐induced histamine release from rat peritoneal cells . R. O. Day, G. D. Champion and D. N. Wade 5. The effects of terbutaline on histamine‐induced dye leakage in guinea‐pig skin . C. G. A. Persson and Stella R. O'Donnell 6. Monitoring of drug therapy at Sydney Hospital . G. M. Eckert and C. G. Berbatis 7. Event‐oriented monitoring studies of drug therapy in a hospital . G. M. Eckert and C. G. Berbatis 8. The use of metoprolol, a selective β‐adrenoceptor blocking agent, for the treatment of hypertension in patients with asthma, or history thereof . A. S. P. Hua and P. Kincaid‐Smith 9. Contrasting actions of four peripherally acting antihypertensive drugs . Helen F. Gates, R. M. Graham, and G. S. Stokes 10. Oxolinic acid in urinary tract infection. S. Kalowski and P. Kincaid‐Smith 11. ED 50 values in anaesthetic patients for thiopentone, methohexital, propanidid and alfathesin using probit and sequential techniques for data analysis . D. P. Crankshaw and J. Allt‐Graham 12. Experimental design simulator (EDS)‐a computer program for the teaching of clinical trial methodology . T. L. Woodings and B. W. Madsen (introduced by J. W. Paterson) 13. Deviation from prescribed treatment in a hypertension clinic: effects of an educational programme . J. Shaw, P. Nieman and J. D. England 14. An exploratory study on the acute adaptation to ethanol . H. M. Franks, G. A. Starmer and R. K. C. Teo 15. Comparative pharmacokinetics of quinine and quinidine in man . A. Lau, G. Graham, D. J. Birkett and S. P. Myers 16. Significance of ‘apparent hydralazine’ levels in plasma of man . P. A. Reece, P. E. Stanley and R. Zacest 17. The effect of age on the pharmacokinetics of warfarin sodium . Kanda Hotraphinyo, E. J. Triggs, B. Maybloom and A. McLean‐Cross (introduced by J. Thomas) 18. Pharmacokinetics of digoxin in thyroid disease . G. M. Shenfield, J. P. Thomson and D. B. Horn (introduced by J. W. Paterson) 19. Salivary antipyrine kinetics in health and disease . A. W. Harman, B. G. Priestley, D. B. Frewin and R. K. Penhall 20. Pancuronium disposition and response . A. A. Somogyi, E. J. Triggs and C. A. Shanks (introduced by J. Thomas) 21. Pharmacokinetics of d ‐tubocurarine chloride in humans . M. I. Ramzan, E. J. Triggs and C. A. Shanks (introduced by J. Thomas) 22. The trachea‐heart selectivity of rimiterol in vitro and in vivo in guinea‐pigs . J. C. Wan‐stall and S. R. O'Donnell 23. Effects of indoramin on two in vitro smooth muscle preparations . J. Black, C. Hamer, D. Temple and S. D. Anderson 24. The effects of monochlorophenethanolamine derivatives on β‐adrenoceptors of guineapigs in vitro . L. G. Letts, D. M. Temple, A. Kilford, Bui Lap, S. N. Quessy and L. Williams 25. Development of cholinergic and adrenergic arousal systems in the rat . H. Bartley and G. Singer 26. Withdrawn.27. Pre‐ and postjunctional effects of clonidine in isolated guinea‐pig atria . I. Medgett and M. W. McCulloch 28. Apparent resistance to the hypotensive effect of clonidine . L. M. H. Wing, J. L. Reid, D. S. Davies, H. J. Dargie and C. T. Dollery (introduced by J. P. Chalmers) 29. The use of isolated human arteries to study the action of prazosin and other hypotensive agents . R. Jauernig and R. F. W. Moulds (introduced by J. Shaw) 30. Effects of prazosin on plasma cyclic AMP levels in man . J. D. England, R. A. Jauernig, P. W. Trembath and J. Shaw 31. Anti‐arrhythmic effect of N‐acetyl procainamide. R . Minchin, K. F. Ilett and J. W. Pater‐son 32. The effect of fatty acids on drug binding sites on human serum albumin . S. P. Myers and D. J. Birkett 33. The disposition of lignocaine in neonates . J. Thomas, G. W. Mihaly, R. G. Moore and E. J. Triggs 34. Perinatal disposition of chlormethiazole used in the management of severe preeclampsia . R. G. Moore, E. Tischler, E. D. Burnard and J. Thomas 35. The protein binding of clonazepam and valproate . D. G. Ferry and E. G. McQueen 36. Protein binding of tolmetin . M. L. Selley, B. W. Madsen and J. Thomas 37. The effect of ethanol on the acquisition of a passive avoidance task . G. Bammer, G. B. Chesher and D. M. Jackson 38. Withdrawal reactions in rats following terf‐butanol administration . R. Laverty and Jeanette Wood 39. Cyclazocine‐induced physical dependence in the rat . F. J. Laska and M. R. Fennessy 40. Intracranial injections of 6‐OHDA: the effect of optimal concentrations on monoamine depletion and consummatory behaviour. G. L. Willis, G. Singer and B. K. Evans 41. Schedule‐induced polydipsia or model for the study of drug intake . G. Singer 42. The effects of intrahypothalamic injections of 6‐OHDA on schedule induced polydipsia . A. McQueen and G. Singer 43. Caffeine‐phenacetin interaction in the rat: effects on absorption, metabolism and locomotor activity . C. Collins, P. T. Richards and G. A. Starmer 44. Subsensitivity to pilocarpine following a single administration of the irreversible anticholinesterase DFP. D. H. Overstreet, S. C. Helps, A. M. Prescott and G. D. Schiller 45. Is malignant hyperpyrexia muscle denervated? R. F. W. Moulds (introduced by J. Shaw) 46. Drug treatment for malignant hyperpyrexia . K. L. Austin and M. A. Denborough (introduced by J. Chalmers) 47. Identification of some constituents of the venom of the Sydney funnel‐web spider, Atrax robustus, using gas chromatography/mass spectrometry. P. H. Duffield, A. M. Duf‐field, P. R. Carroll and D. Morgans 48. Adrenergic activity of components of the venom of the Sydney funnel‐web spider, Atrax robustus. P. R. Carroll, D. Morgans, A. M. Duffield and P. H. Duffield 49. Toxicity due to drug metabolism: direct evidence . M. J. Cousins (introduced by L. B. 50. The toxicity of halogenated volatile anaesthetics in isolated rat hepatocytes. N. H. Stacey, B. G. Priestly and R. C. Hall 51. The effects of hepatoprotective treatments on CCI 4 toxicity in isolated rat hepatocyte suspensions. N. H. Stacey and B. G. Priestly 52. Adverse reactions to drugs: a twelve‐month hospital survey . K. A. McMahon, D. B. Frewin, E. G. Easterbrook, E. A. Hender, T. I. Lee and P. K. Penhall 53. Pharmacokinetics of 14 C‐haloperidol in man. K. F. Ilett, A. E. Mackie, L. B. Jellett, B. W. Madsen, K. Somers and I. E. Hughes 54. Comparison of direct and indirect pharmacokinetic methods for assessing hepatic clearance of drugs. L. E. Mather and G. T. Tucker (introduced by J. Chalmers) 55. Disopyramide pharmacokinetics and bioavailability . D. K. Dubetz, N. N. Brown, W. D. Hooper, M. J. Eadie and J. H. Tyrer 56. The continuing saga of in vivo‐in vitro bioavailability evaluations‐a study with sulphi‐soxazole . G. W. A. Slywka, P. L. Whyatt and M. C. Meyer 57. The pharmacokinetics of Iabetalol and its effects on blood pressure and plasma noradrenaline and plasma renin in hypertension . M. J. Brignell, L. J. Graf and W. J. Louis 58. Comparison of serum drug concentrations during a clinical trial of benorylate, acetyl salicylic acid and paracetamol with acetyl salicylic acid . P. J. Keary, R. Laurent and D.G. Ferry 59. Pharmacokinetics of carprofen in man . J. E. Ray, J. O. Bostrom and D. N. Wade 60. The effects of isoprenaline inhalation on arteriovenous differences in plasma cyclic AMP levels in dogs . P. W. Trembath and J. Shaw 61. The demonstration of an increase in dopamine receptor responsiveness after long term administration of dexamphetamine to mice . R. Bailey and D. M. Jackson 62. The uptake and release of octopamine by mammalian brain . G. Sudlow, D. F. H. Dougan and D. N. Wade 63. Uptake and removal of noradrenaline and isoprenaline by the hypothalamus of the possum. J. Minson and R. C. Hall 64. Interaction of caffeine with intracerebral dexamphetamine on locomotor activity of rats P. Braes and D. M. Jackson 65. Cholinergic hyposensitivity in mice after withdrawal from long‐term haloperidol treatment. Robin Dunstan and D. M. Jackson 66. An effect of ethanol at a glutamate synapse. O. P. Hamill, D. J. Adams and P. W. Gage (introduced by P. R. Carroll) 67. Withdrawn by authors.68. Vasodilator response to guanethidine mediated by endogenous histamine . J. A. Angus, A. Bobik and P. I. Korner 69. Effects of intraventricular injections of histamine on arterial blood pressure and heart rate in conscious rabbits . E. Malta, P. R. C. Howe, J. C. Lloyd and J. P. Chalmers 70. Blockade by phentolamine of the potentiating action of tetraethylammonium in the rabbit ear artery . P. R. Carroll and D. Morgans 71. Effects of prostaglandins on vasoconstriction in the rat mesentery . P. L. McLennan and I. M. Coupar (introduced by A. L. A. Boura) 72. Differential effects of digoxin at comparable concentrations in tissues of foetal and adult sheep . P. J. Ravenscroft, W. Berman, L. B. Sheiner, M. A. Heymann, K. L. Melmon and A. M. Rudolph 73. Coronary vasodilatation elicited by electrical stimulation of the canine hypothalamus . R. Padanyi, W. J. Lang and C. Bell 74. Responses of sheep coronary arteries to transmural stimulation . E. J. Cornish, R. C. Miller and F. G. Brine 75. Mechanism of inhibition of tolbutamide metabolism by phenylbutazone and oxyphen‐butazone . S. M. Pond, D. J. Birkett and D. N. Wade 76. Time course of cadmium‐induced inhibition of hepatic microsomal enzymes in the rat. P. G. Peters and B. G. Priestly 77. Comparative study of 14 C‐phenanthrene in hepatic microsomal systems. S. Chaturapit, G. M. Holder and D. M. Jerina (introduced by Professor J. Thomas) 78. A 14 C‐phenacetin breath test in the assessment of hepatic drug clearance . P. V. Desmond, K. J. Breen, R. W. Bury, I. Calder and M. L. Mashford 79. The metabolism of styrene oxide in the isolated perfused rat liver . A. J. Ryan and J. R. Bend (introduced by J. Thomas) 80. The absorption of benorylate in an in vitro everted rat small intestine model . P. Paull, D. N. Wade and G. G. Graham 81. Biliary excretion of rifampicin in the conscious pig . N. G. Kingsley, S. Jeffries, M. Rose and J. M. Ham 82. α‐Adrenoreceptor blockade by oxprenolol . M. Law, M. J. Rand and D. F. Story 83. β‐Adrenoreceptors in hearts and kidneys of hypertensive rats . E. A. Woodcock, C. I. Johnston, N. M. A. Walter and J. W. Funder 84. Haemodynamic effects of oxprenolol during anaesthesia: dose‐response studies. J. G. Roberts and P. Foex (introduced by L. B. Geffen) 85. Catecholamines based on the phenoxypropanolamine nucleus: activity in the anaesthetized cat. G. S. Keh and C. Raper 86. The use of fluorescence histochemistry to compare isoprenaline accumulation in trachea and atria of guinea‐pig and cat . E. N. Anning, L. J. Bryan and S. R. O'Donnell 87. Cardiovascular aspects of the action of substance P. R. W. Bury and M. L. Mashford 88. Patterns of changes in plasma levels of valproate and phenytoin in patients on multiple anticonvulsant therapy . F. J. E. Vajda and P. M. Morris 89. Factors influencing plasma phenobarbitone levels in epileptic patients . C. M. Lander, M. J. Eadie.W. D. Hooper and J. H. Tyrer 90. Phenytoin tracer half‐lives in epileptic and non‐epileptic subjects . A. Richens (introduced by M. J. Eadie) 91. Pharmacokinetics of ethosuximide in man . L. McKauge, G. A. Smith, J. H. Tyrer and M. J. Eadie 92. Pharmacokinetics and interactions of valproate in man. G. A. Smith, L. McKauge, J. H. Tyrer and M. J. Eadie 93. The calculation of repititive dose accumulation for non‐linear pharmacokinetic systems. W. J. O'Reilly 94. The effect of calcium on the interaction between acetylcholine and noradrenergic transmission in the rabbit ear artery . W. Hope, M. W. McCulloch, M. J. Rand and D. F. Story 95. Dopamine‐β‐hydroxylase content and activity in purified noradrenergic vesicles . R. L. Klein, D. F. Kirksey, R. A. Rush and M. Goldstein (introduced by L. B. Geffen) 96. Metabolism of noradrenaline in the rabbit ear artery. I. S. de la Lande, R. J. Head and D. A. S. Parker 97. The effect of ovarian steroids on the metabolism of noradrenaline in the rabbit uterus . I. S. de la Lande and J. A. Kennedy 98. Pharmacokinetics of pranolium chloride in normal volunteers . M. C. Kennedy, J. C. Middleton and D. N. Wade 99. Pharmocokinetic studies of prindolol in man. A. Bobik , G. Jennings and P. I. Korner 100. Clinical effects of prindolol in man and their relationship to plasma concentration. G. L. Jennings, A. Bobik, E. Fagan and P. I. Korner 101. Pharmacokinetics of metoprolol in hypertensive patients . A. J. Wood, H. J. Waal‐Manning and P. Bolli 102. Characteristics of in vitro accumulation of 14 C‐haIoperidol by rat lung . L. D. Brett, K. F. Ilett and J. W. Paterson 103. A morphine‐sensitive dopaminergic interneurone in the Myenteric plexus of the guinea‐pig ileum . R. L. Heimans (introduced by M. J. Rand) 104. Histochemical and pharmacological studies of aminergic neurones in the guinea‐pig small intestine . M. Costa and J. B. Furness 105. Levodopa metabolites and side effects of levodopa therapy . M. W. Nott 106. Dopaminergic nerves in vascular control . W. J. Lang and C. Bell 107. Sites of drug action on nigrostriatal dopaminergic neurones . L. B. Geffen 108. Modulation of transmitter release from sympathetic nerves by dopamine . D. F. Story, W. Hope, M. W. McCulloch and M. J. Rand 109. Dopamine, the mesolimbic system and behaviour . D. M. Jackson, P. U. Braes, R. Dunstan and J. Engel 110. Dopamine and hypothalamic‐pituitary neuroendocrine control . G. Smythe and L. Lazarus 111. The use of methyldopa in the treatment of Huntinton's chorea . E. L. Conway, B. Jarrott, J. McNeil and W. J. Louis 112. The biosynthesis of dopamine and noradrenaline . W. J. Louis, A. Culvenor, B. Jarrott, L. Adams and O. Drummer