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CLINICAL DOSE‐RESPONSE STUDIES WITH GUANFACINE (BS 100‐141), A NEW ANTIHYPERTENSIVE AGENT
Author(s) -
MacCarthy P.,
Isaac P.,
Frost G.,
Freeman A.,
Stokes G.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00669.x
Subject(s) - guanfacine , sedation , clonidine , medicine , blood pressure , pulse rate , anesthesia , oral administration , heart rate , blood flow , pharmacology
SUMMARY 1. Blood pressure, pulse rate, salivary flow and the degree of sedation were recorded at intervals following oral administration of single doses of guanfacine, a clonidine‐like agent, to hypertensive patients. 2. Between 2 and 10 h after administration of guanfacine (3 mg or S mg), there were dose‐related decreases in lying and standing blood pressure, together with significant reductions in pulse rate and salivary flow. 3. It is concluded that guanfacine lowers blood pressure in hypertensive patients and is probably suitable for twice daily administration, but produces xerostomia and sedation.