Premium
INCREASED BILIARY EXCRETION OF OUABAIN INDUCED BY BUCOLOME IN THE RAT
Author(s) -
Kitani K.,
Kanai S.,
Miura R.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00661.x
Subject(s) - ouabain , excretion , medicine , endocrinology , chemistry , sodium , organic chemistry
SUMMARY 1. Following the intravenous injection of 3 H‐ouabain (0.4 or 0.6 mg/100 g body weight) the plasma concentration and biliary excretion of ouabain were compared for control male Wistar rats and rats given bucolome (BC, l‐cyclohexyl‐5‐ n ‐butyl‐2,4,6,‐trioxoperhydroxypyrimidine, 20 mg/100 g) 40 min before the ouabain injection. In bucolome treated rats, the bile flow rate was 80–90% higher than in control rats and the biliary excretion rate of ouabain for the 40 min post‐injection period was significantly higher in bucolome treated rat groups. The increase was due to an approximately two‐fold increase in the excretion rate in the first 10 min period. On the other hand, plasma concentration of ouabain was significantly higher in bucolome treated rats compared with control rats at corresponding time intervals. Plasma volume as determined by 131 I‐labelled albumin dilution was not decreased in bucolome treated rats. 2. The results indicated that the significant increase in biliary excretion of ouabain administration was due to the enhancement of the hepatic transport and/or biliary excretion process and not due to an increase in hepatic uptake.