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MODIFICATION OF BRAIN BIOGENIC AMINES BY MET S ‐ENKEPHALIN AMIDE IN THE RAT
Author(s) -
Laska F. J.,
Fennessy M. R.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00658.x
Subject(s) - enkephalin , amide , chemistry , biogenic amine , met enkephalin , stereochemistry , serotonin , biochemistry , receptor , opioid
SUMMARY 1.Gross changes in behaviour and whole brain levels of noradrenaline, dopamine, serotonin and 5‐hydroxyindoleacetic acid were examined in rats for 3 min following intracerebral injections of met 5 ‐enkephalin amide or morphine. 2. Both the enkephalin and morphine depressed respiration and induced a cataleptic‐like state, but only the enkephalin produced wet‐shake responses. 3. All doses of met 5 enkephalin amide (150, 200 and 600μg) and morphine (134 and 200 /Kg) increased the brain levels of 5‐hydroxyindoleacetic acid, whereas only the large doses modified the levels of noradrenaline and serotonin. 4. The similarity of the effects of these two compounds indicates that morphine may act through an enkephalin‐like mechanism.