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THE INFLUENCE OF SEROTONIN ON THE MITOTIC RATE IN THE COLONIC CRYPT EPITHELIUM AND IN COLONIC ADENOCARCINOMA IN RATS
Author(s) -
Tutton P. J. M.,
Barkla D. H.
Publication year - 1978
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1978.tb00657.x
Subject(s) - serotonin , crypt , mitosis , 5 ht receptor , medicine , endocrinology , adenocarcinoma , dimethylhydrazine , enterochromaffin cell , chemistry , cell , descending colon , epithelium , biology , receptor , colorectal cancer , biochemistry , pathology , rectum , microbiology and biotechnology , cancer
SUMMARY 1. The mitotic rate in the crypts of Lieberkiihn of the descending colon and in dimethylhydrazine‐induced adenocarcinomata of the descending colon of rat was measured using a stathmokinetic technique. 2. Intraperitoneal injection of a small dose (10 jug/kg) of serotonin resulted in an increase in the tumour cell mitotic rate. 3. Blockade of serotonin receptors by 2‐bromolysergic acid diethylamide and depletion of tissue serotonin levels following injection of DL‐6‐fluorotryptophan both result in a decrease in the tumour cell mitotic rate. 4. Treatment with serotonin, 2‐bromolysergic acid diethylamide and DL‐6‐fluorotryptophan were all without effect on the colonic crypt cell mitotic rate.