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EVALUATION OF DRUG‐INDUCED RENO‐RENAL VASOMOTOR REFLEX IN THE DOG
Author(s) -
Robie N. W.
Publication year - 1977
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1977.tb02690.x
Subject(s) - vasomotor , medicine , reflex , drug , anesthesia , cardiology , pharmacology
SUMMARY 1. Renal arterial infusions of endogenous vasoactive compounds were administered, and electromagnetic flow probes were used to measure simultaneous ipsilateral and contralateral renal blood flow. 2. The expected ipsilateral renal blood flow changes resulting from infusions of acetylcholine, noradrenaline, angiotension II, bradykinin and PGE 2 were observed. There were no transient, phasic or sustained contralateral renal blood flow changes. 3. These results suggest that a previously hypothesized reno‐renal vasomotor reflex communication does not exist. The discrepancies between these present studies and previous ones proposing such a reflex may be due to the methods chosen for measurement of renal blood flow.