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INHIBITION OF BOVINE CEREBRAL CORTEX PROSTAGLANDIN SYNTHETASE BY PHENOXYBENZAMINE AND CYPROHEPTADINE IN VITRO
Author(s) -
Kandasamy S. B.
Publication year - 1977
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1977.tb02689.x
Subject(s) - cyproheptadine , phenoxybenzamine , phentolamine , prostaglandin , chemistry , in vitro , endocrinology , pharmacology , medicine , cerebral cortex , serotonin , biochemistry , receptor
SUMMARY 1. Bovine cerebral cortex (BCC) microsomes were isolated from fresh brain using standard techniques. 2. Two a ‐adrenoceptor antagonists (phenoxybenzamine and phentolamine) and two anti‐serotonin compounds (cyproheptadine and cinanserine) were compared with the anti‐inflammatory drugs indomethacin and keptoprofene for inhibition in vitro of prostaglandin (PG) synthetase. 3. Phenoxybenzanine and cyproheptadine inhibited BCC PG synthetase in vitro , but their potency was 1% that of indomethacin and keptoprofene. Phentolamine and cinanserine did not inhibit PG synthetase in concentrations up to ten times the effective concentrations of the other test drugs. 4. It is suggested that the antipyrogenic effect of phenoxybenzamine and cyproheptadine may be due to their inhibitory effect on prostaglandin synthesis.