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PROSTAGLANDINS: ANTINOCICEPTIVE EFFECT OF PROSTAGLANDIN E 1 IN THE RAT
Author(s) -
Sanyal A. K.,
Bhattacharya S. K.,
Keshary P. R.,
Srivastava D. N.,
Debnath P. K.
Publication year - 1977
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1977.tb02621.x
Subject(s) - morphine , chemistry , pharmacology , nociception , methysergide , reserpine , serotonin , analgesic , prostaglandin e1 , prostaglandin , prostaglandin e , prostaglandin f2alpha , prostaglandin e2 , endocrinology , medicine , receptor , biochemistry
SUMMARY 1. The antinociceptive effect of prostaglandins E 1 , E 2 and F 2α was studied in albino rats. Though all three prostaglandins produced similar degrees of sedation, only prostaglandin E 1 (PGE 1 ) produced a dose‐related antinociceptive activity. 2. The antinociceptive activities of equi‐analgesic doses of morphine (7.5 mg/kg, i.p.) and PGE 1 (2.0 mg/kg, i.p.) were inhibited to almost similar extents after pretreatment with drugs known to reduce central turnover of serotonin receptors, namely reserpine, fenclonine ( p ‐chlorophenylalanine), methysergide and 5,6‐dihydroxytryptamine. 3. Prostaglandin F 2α (2.0 mg/kg, i.p.) significantly inhibited the antinociceptive effects of both morphine and PGE 1 . 4. The prostaglandin synthesis inhibitors, indomethacin and diclofenac, significantly inhibited morphine analgesia. 5. Probenecid markedly prolonged the duration of antinociceptive effect of morphine and the duration of PGE 1 ‐induced potentiation of subanalgesic dose of morphine. 6. The results suggest that, in albino rats, PGE 1 ‐induced antinociceptive activity is serotonin mediated and that morphine analgesia is not only mediated through serotonin but also through prostaglandins (PGE 1 ?) and 5‐hydroxyindole acetic acid, the serotonin metabolite.