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EFFECTS OF CLONIDINE ON VASCULAR RESPONSES IN KIDNEY AND HINDLIMBS OF CATS
Author(s) -
Hepburn E. R.,
Reynoldson J. A.,
Li D. M. F.,
Bentley G. A.
Publication year - 1976
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1976.tb00642.x
Subject(s) - clonidine , hindlimb , vasoconstriction , reflex , medicine , cats , kidney , endocrinology , anesthesia
SUMMARY 1. Cardiovascular reflexes to intravenous adrenaline and histamine and to carotid occlusion were studied in the renal vasculature, and direct effects of nor‐adrenaline and clonidine were compared in renal and hindlimb vascular beds in anaesthetized cats. 2. Unlike its reported effects on cardiovascular reflexes in the hindlimbs, clonidine depressed all three reflexes in the kidneys. 3. Noradrenaline caused vasoconstriction when given directly into both renal and hindlimb circulations, but clonidine produced vasoconstriction only in the hindlimb vascular bed. 4. These results suggest that α‐adrenoceptors in the renal vasculature may be different from those in the hindlimbs, and that the cardiovascular reflexes in these two areas are under different control.