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RENAL RESPONSES TO SLIGHT ELEVATIONS OF RENAL ARTERIAL PLASMA ANGIOTENSIN II CONCENTRATION IN DOGS
Author(s) -
Fagard Robert H.,
Cowley Allen W.,
Navar L. Gabriel,
Langford Herbert G.,
Guyton Arthur C.
Publication year - 1976
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1976.tb00634.x
Subject(s) - renal function , chemistry , angiotensin ii , endocrinology , medicine , renal blood flow , filtration fraction , effective renal plasma flow , renal artery , urine flow rate , renin–angiotensin system , kidney , excretion , blood pressure
SUMMARY 1. Angiotensin II was infused into the renal artery of intact kidneys of slightly volume expanded anaesthetized dogs at rates of 125, 250, 500, and 1000 pg/kg body weight per min, resulting in elevations of the calculated renal arterial plasma angiotensin II concentration of 16·9 (s.e.m. = 2·1), 35·0 (s.e.m. = 4·3), 73·3 (s.e.m. = 8·8), and 159·8 (s.e.m. = 20·4) pg/ml. 2. Angiotensin II caused significant dose‐dependent decreases of renal blood flow and of renal plasma flow of ‐4·1% (s.e.m. = 1·5, P (0·05) at the lowest and of ‐19·6% (s.e.m. = 1·4, P (0·001) at the highest rate of infusion. Glomerular filtration rate remained essentially unchanged at the two lower infusion levels and decreased by ‐6·7% (s.e.m. = 2·2, P (0·05) and ‐8·3% (s.e.m. = 2·5, P (0·05) at the higher rates of infusion. Filtration fraction thus increased by +6·3% (s.e.m. = 2·4, P (0·05) at the lowest and by +14·2% (s.e.m. = 3·6, P (0·01) at the highest rate of infusion. 3. Urine volume decreased by ‐7·7% (s.e.m. = 0·8, P (0·001) at the lowest and by ‐35·2% (s.e.m. = 4·8, P (0·001) at the highest rate of infusion, while the study showed similar dose‐dependent decreases for urinary sodium and potassium excretion and for the fraction of filtered sodium excreted.