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THE INFLUENCE OF HISTAMINE ON EPITHELIAL CELL PROLIFERATION IN THE JEJUNUM OF THE RAT
Author(s) -
Tutton P. J. M.
Publication year - 1976
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1976.tb00613.x
Subject(s) - histamine , metiamide , mepyramine , mitosis , jejunum , crypt , histamine h4 receptor , histamine h1 receptor , epithelium , histamine receptor , medicine , endocrinology , chemistry , biology , receptor , histamine h2 receptor , microbiology and biotechnology , biochemistry , antagonist , genetics
SUMMARY 1. The influence of histamine and histamine receptor blockade on the mitotic rate in epithelial cell proliferation in epithelial cells lining the crypts of Lieberkühn in rat jejunum was studied. 2. Histamine injection resulted in an increase in the mitotic rate. This increase in mitotic rate was blocked by metiamide but not by mepyramine. 3. Prevention of histamine synthesis by α‐methylhistidine administration did not alter the mitotic rate. 4. The mechanism by which histamine may influence crypt cell proliferation and and possible role of cyclic GMP in this mediation are discussed.