Premium
ON THE ROLE OF SEROTONIN IN THE PATHOGENESIS OF PULMONARY HYPERTENSION INDUCED BY ANORECTIC DRUGS; AN EXPERIMENTAL STUDY IN THE ISOLATED PERFUSED RAT LUNG II. FENFLURAMINE, MAZINDOL, MEFENOREX, PHENTERMINE AND R 800
Author(s) -
Seiler K.U.,
Wassermann O.,
Wensky H.
Publication year - 1976
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1976.tb00608.x
Subject(s) - phentermine , fenfluramine , anorectic , mazindol , medicine , serotonin , pulmonary hypertension , pathogenesis , pharmacology , lung , endocrinology , body weight , dopamine , obesity , weight loss , receptor
SUMMARY 1. The influence of the anorectic drugs fenfluramine, mazindol, mefenorex, phentermine and R 800, an experimental compound, on pulmonary vascular resistance has been studied in the isolated, perfused rat lung. 2. R 800 caused a strong vasoconstriction, which was not antagonized by methysergide or phentolamine; the other drugs listed did not alter vascular resistance. 3. Mazindol and phentermine significantly prolonged the vasoconstrictive effect of serotonin due to inhibition of its metabolic breakdown. 4. Although fenfluramine inhibited serotonin metabolism it also prevented the vasoconstrictive effect of serotonin, due to its ability to act as a serotonin antagonist. 5. Mefenorex did not affect pulmonary vascular resistance, either directly or indirectly via a serotoninergic mechanism.