Premium
A diminution of enzyme release in the anoxic guinea‐pig heart observed after cardoiplegic treatment
Author(s) -
Sakai K.,
Gebhard M. M.,
Spieckermann P. G.
Publication year - 1976
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1976.tb00605.x
Subject(s) - lactate dehydrogenase , anaerobic exercise , creatine kinase , malate dehydrogenase , guinea pig , enzyme , anoxic waters , creatine , chemistry , dehydrogenase , medicine , biochemistry , endocrinology , pharmacology , biology , physiology , environmental chemistry
SUMMARY 1. Under anaerobic conditions there was an increase in the release of malate dehydrogenase, lactate dehydrogenase and creatine phosphokinase from isolated perfused guinea‐pig hearts. 2. The increased enzyme releases were significantly reduced by pretreatment with cardioplegic solution. 3. This finding suggests a relationship between myocardial energy metabolism and enzyme release or retention.