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DIFFERING EFFECTS OF THE VASODILATOR DRUGS, PRAZOSIN AND DIAZOXIDE ON PLASMA RENIN ACTIVITY IN THE DOG
Author(s) -
Graham R. M.,
Muir M. R.,
Hayes J. M.
Publication year - 1976
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1976.tb00602.x
Subject(s) - prazosin , diazoxide , plasma renin activity , vasodilation , medicine , blood pressure , renin–angiotensin system , endocrinology , pharmacology , insulin , antagonist , receptor
SUMMARY 1. The effects of intravenous (i.v.) administration of the vasodilator drugs prazosin or diazoxide on blood pressure and plasma renin activity were evaluated in the anaesthetized dog. 2. Prazosin and diazoxide both induced a rapid reduction in the mean arterial pressure to 73% and 75% of control values respectively. 3. Prazosin Iowered plasma renin activity to 62% ( P < 0.025) of the control value whereas diazoxide raised plasma renin activity to 178% ( P < 0.05) of the control value. 4. The combination of vasodilatation and low renin activity observed following the administration of prazosin is unique, and may have clinical significance if these factors reduce the vascular complications of hypertension.